Abacavir Impurity E; Abacavir Impurities; Abacavir EP Impurity E
杂质:
Abacavir EP Impurity E
CAS号:
208762-35-0
分子式:
C₁₄H₂₀N₆O
状态：
白色固体
熔点：
>80°C (dec.)
分子量:
288.35
储存：
-20°C Freezer
溶解性:
Methanol (Slightly), Water (Slightly)
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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