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| 产品基本信息 |
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| 产品编号：O848430 |
| 产品名称：(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1, |
| 产品CAS：151792-53-9 |
| 规格含量：5g |
| 产品价格：面议 |
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| 产品详细介绍 |
| 标准品编号: |
O848430 |
| 名称: |
(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1,1-Dimethylethyl Ester |
| 别名: |
(1R,4S)-(-)-2-t-Butoxycarbonyl-2-azabicyclo[2.2.1]hept-5-en-3-one; (1R,4S)-t-Butyl 3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; (1R)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid 1,1-Dimethylethyl Ester |
| CAS号: |
151792-53-9 |
| 分子式: |
C₁₁H₁₅NO₃ |
| 分子量: |
209.24 |
| 类别: |
Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: |
(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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![(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1,](/images/defaultpic.gif "(1R,4S)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid 1,")
