N-[4-(3-Pyridinyl)phenyl]-4-morpholinepentanamide; WAY 317538;
CAS号:
874450-44-9
分子式:
C₂₀H₂₅N₃O₂
分子量:
339.43
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
SEN 12333 is a nicotinic acetylcholine receptor (nAChR) agonist. SEN 12333 displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. SEN 12333 is a brain penetrant and orally bioavailable.
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