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产品基本信息
产品编号：Z623505
产品名称：Zoledronic acid
产品CAS：118072-93-8
规格含量：25mg
产品价格：面议
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产品详细介绍
标准品编号:
Z623505
名称:
Zoledronic acid
别名:
P,P'-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic Acid; [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid; (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene-1,1-bisphosphonic acid; 2-(Imidazol-1-yl)-1-hydroxy-1,1'-ethylidenediphosphonic acid; Aclasta; BPH 91; CGP 42446; Orazol; Reclast; ZOL 446; Zoledronate; Zoledronic acid; Zometa
CAS号:
118072-93-8
分子式:
C₅H₁₀N₂O₇P₂
外观:
白色至白色固体
熔点:
>210°C (Subl.)
分子量:
272.09
储存:
Hygroscopic, 冰箱, under inert atmosphere
溶解度:
Water (Slightly)
稳定性:
extremely hygroscopic
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
参考文献
Jagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686. Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.
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