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产品基本信息
产品编号：B810545
产品名称：BX 471
产品CAS：217645-70-0
规格含量：5mg
产品价格：面议
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产品详细介绍
标准品编号:
B810545
名称:
BX 471
别名:
(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine; (2R)-1-[[[4-Chloro-2-(ureido)phenoxy]methyl]carbonyl]-2-methyl-4-(4-fluorobenzyl)piperazine; N-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]urea
CAS号:
217645-70-0
分子式:
C₂₁H₂₄ClFN₄O₃
分子量:
434.89
类别:
Standards; Enzyme Activators and Inhibitors;
应用:
BX 471 iS A C-C chemokine receptor 1(CCR1) antagonist. The CCR1 is implicated in diseases such as multiple myeloma, rheumatoid arthritis, and multiple sclerosis and therefore BX 471 may be used in treatment of such diseases.
参考文献
Meritt, J., et al.: J. Med. Chem., 52, 1295 (2009); Choi, S., et al.: Chemokine-inhibiting piperazine derivatives and their use to treat multiple myeloma, WO Patent 2005077372, Aug 25, 2005;
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