(1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites
杂质:
Abacavir - In House Impurity
CAS号:
136470-77-4
分子式:
C₁₄H₁₉N₆O₄P
状态：
白色固体
熔点：
189-194°C (dec.)
分子量:
366.31
储存：
-20˚C Freezer
溶解性:
Methanol, Water
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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