[1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester; O 371;
CAS号:
130342-80-2
分子式:
C₁₆H₂₀ClNO₂
外观:
白色固体
熔点:
116-119°C
分子量:
293.79
储存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:
Chloroform (Slightly), Methanol (Sparingly)
稳定性:
Hygroscopic
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
RTI-COC 31 is a potent phenyltropane cocaine analog which exhibits inhibitory interactions with serotonergic neurons. Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
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