(E)-Ethyl 4-(4-Benzylphenyl)-2-((ethoxymethylene)amino)thiophene-3-carboxylate is an intermediate in synthesizing Barbadin (B118250), a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.
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