A S-substituted L-cysteine derivative used for the manufacture of a topical medicament or a cosmetic agent useful to improve conditions and to alleviate the symtoms of dermatologic disorders related to the impairment of lipid metabolism, suitable for the treatment of edematous-fibrosclerotic panniculopathy, ichthyosis, hyperkeratosis, Darier disease, lichen simplex chronicus, keloid, scar, acne, rosacea and couparose.