4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;
CAS号:
763111-49-5
分子式:
C₂₁H₂₁FN₄O₂
外观:
Pale Yellow to Yellowish Beige Solid
熔点:
>150°C (dec.)
分子量:
380.42
储存:
冰箱
溶解度:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro
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