3-(Piperazin-1-yl)pyrrolidine-1-carboxylic Acid tert-Butyl Ester-d8, is the labeled analogue of 3-(Piperazin-1-yl)pyrrolidine-1-carboxylic Acid tert-Butyl Ester (P479915), which can be used in the synthesis of a a novel series of indazoles as ketohexokinase inhibitors, that are also shown to be lead-like compounds with good pharmaceutical properties.