1,4-Piperazinediethylamine-d8 is the isotope labelled analog of 1,4-Piperazinediethylamine (P480090); a reagent in the synthesis of bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors. Also used as a reagent in the synthesis of novel bisnaphthalimides as new DNA topoisomerase II inhibitors.