(2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide; UK 356618; PF-03890101;
CAS号:
230961-08-7
分子式:
C₃₄H₄₃N₃O₄
外观:
Beige Solid
熔点:
93-102ºC
分子量:
557.72
储存:
-20˚C Freezer
溶解度:
Methanol (Slightly)
类别:
Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
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