6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin VIP(LA)d4; ISATX 247-d4; R 1524-d4; trans-ISA 247-d4;
参考CAS号:
515814-01-4-unlabelled
分子式:
C₆₃H₁₀₇D₄N₁₁O₁₂
外观:
白色至白色固体
熔点:
>129°C (dec.)
分子量:
1218.65
储存:
Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度:
Benzene (Slightly), Methanol (Slightly)
类别:
Standards; Isotopic Labeled Analogues; Amino Acids/Peptides; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Labelled Voclosporin (V678500). A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. Immunosuppressant.
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