P-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate TEA Salt
备用CAS:
Free acid: 137820-58-7
分子式:
C₁₄H₂₁N₆O₁₀P₃ • xC ₆H₁₅N
状态：
灰白色至浅褐色固体
熔点：
>104C (dec.)
分子量:
526.2710119
储存：
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
类别:
Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
应用:
Abacavir Triphosphate TEA Salt, is a metabolite of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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