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| 产品基本信息 |
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| 产品编号：A595930 |
| 产品名称：(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol |
| 产品CAS：216481-88-8 |
| 规格含量：10mg |
| 产品价格：面议 |
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| 产品详细介绍 |
| 标准品编号: |
A595930 |
| 名称: |
(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol |
| CAS号: |
216481-88-8 |
| 分子式: |
C₁₁H₁₂ClN₅O |
| 分子量: |
265.7 |
| 类别: |
Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: |
(1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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