N-Oleoylethanolamide-d4 is the labeled analogue of N-Oleoylethanolamide (O527280), an agonist of peroxisome proliferator-activated receptor-α (PPAR-α). N-Oleoylethanolamide generates an intestinal signal that stimulates central dopamine activity establishing a link between caloric-homeostatic and hedonic-homeostatic controllers. N-Oleoylethanolamide-d4 is a selective GPR55 agonist.