3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine; 1,3-Dimethyl-5-adamantanamine; 1,3-Dimethyl-5-aminoadamantane; 1-Amino-3,5-dimethyladamantane 3,5-Dimethyl-1-adamantanamine; 3,5-Dimethyl-1-adamantylamine; Alzantin D 145; D 145 (sympathomimetic); DMAA; DRG 0267; Ebixa; Memantina
CAS号:
19982-08-2
分子式:
C₁₂H₂₁N
外观:
Clear Colorless Oil to Off-White Waxy Solid
熔点:
未标明外观
分子量:
179.3
储存:
冰箱, under inert atmosphere
溶解度:
Chloroform (Slightly), DMSO (Slightly)
种类:
Standards; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer's disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.
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