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产品基本信息
产品编号：M312775
产品名称：Methyl (S)-(+)-3-Hydroxy-2-methylpropionate
产品CAS：80657-57-4
规格含量：500mg
产品价格：面议
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产品详细介绍
标准品编号:
M312775
名称:
Methyl (S)-(+)-3-Hydroxy-2-methylpropionate
别名:
(+)-Methyl β-Hydroxyisobutyrate; (2S)-3-Hydroxy-2-methylpropanoic Acid Methyl Ester; (2S)-3-Hydroxy-2-methylpropionic Acid Methyl Ester; (S)-(+)-Roche Ester; (S)-2-Methyl-3-hydroxypropionic Acid Methyl Ester; (S)-3-Hydroxy-2-methylpropanoic Acid Methyl Ester; (S)-3-Hydroxy-2-methylpropionic Acid Methyl Ester; (S)-Roche Ester; Methyl (2S)-2-Hydroxymethylpropanoate; Methyl (2S)-3-Hydroxy-2-methylpropionate; Methyl (S)-(+)-3-Hydroxy-2-methylpropionate; Methyl (S)-2-Methyl-3-hydroxypropionate; Methyl (S)-3-Hydroxy-2-methylpropanoate; Methyl (S)-3-Hydroxy-2-methylpropionate; Methyl (S)-3-Hydroxyisobutanoate; Methyl (S)-β-Hydroxyisobutyrate; Methyl 3-Hydroxy-(2S)-methylpropanoate
CAS号:
80657-57-4
分子式:
C₅H₁₀O₃
外观:
Clear Colorless Oil
分子量:
118.13
储存:
冰箱, under inert atmosphere
溶解度:
Chloroform (Slightly), Methanol (Slightly)
种类:
Building Blocks; Chiral Molecules;
应用:
Methyl (S)-(+)-3-Hydroxy-2-methylpropionate is an intermediate used to prepare alkoxy- or alkylamino-substituted isoindolinones as inhibitors of the MDM2-p53 protein-protein interaction. It is also used in the synthesis of aliskiren (46, CGP060536B, SPP100), a highly potent, selective inhibitor of renin used for the treatment of hypertension.
参考文献
Hardcastle, I., et al.: J. Med. Chem., 49, 6209 (2006); Maibaum, J., et al.: J. Med. Chem., 50, 4832 (2007)
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