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产品基本信息
产品编号：M425460
产品名称：MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid
产品CAS：
规格含量：2.5mg
产品价格：面议
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产品详细介绍
标准品编号:
M425460
名称:
MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid
别名:
L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteine trifluoroacetic acid; 132: PN: US20050020811 SEQID: 125 Claimed Sequence; 13: PN: WO2014151200 SEQID: 56 Claimed Protein; 44: PN: US20120237593 SEQID: 56 Claimed Sequence; 5: PN: WO2016015055 SEQID: 6 Claimed Sequence; 652: PN: WO2007022531 PAGE: 248 Claimed Protein; 65: PN: WO2005087797 SEQID: 71 Unclaimed Sequence; 78: PN: US20090062207 SEQID: 81 Unclaimed Protein; 80: PN: US20060281682 SEQID: 81 Claimed Protein; 81: PN: US20060258593 SEQID: 81 Unclaimed Protein; 90: PN: WO2008106429 PAGE: 4/64 Unclaimed Protein; 9: PN: WO2010027405 SEQID: 9 Claimed Protein;
参考CAS号:
832118-08-8
分子式:
C₅₀H₇₆N₁₄O₁₉S₆ • x(C ₂HF₃O₂)
外观:
白色固体
熔点:
>261°C (dec.)
分子量:
1369.61114
储存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
MM-419447 is a Linaclotide metabolite, which is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
参考文献
Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);
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