1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine; 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine; API 2; NSC 154020; TCN;
CAS号:
35943-35-2
分子式:
C₁₃H₁₆N₆O₄
外观:
白色至淡黄色固体
熔点:
211-214°C (dec.)
分子量:
320.3
储存:
-20˚C Freezer
溶解度:
DMSO, Methanol (Slightly, Heated)
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
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