17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide-d8 (deuterium labeled) is an inhibitor of sodium/hydrogen exchanger isoform 3 (NHE3), which is a major absorptive sodium transporter. It has therapeutic potential for lowering gastrointestinal sodium absorption and improving fluid overload-related symptoms, such as hypertension and proteinuria, in patients with CKD.
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