Trimethyl-4-phosphonocrotonate is used in the preparation of thiazole derivatives related to leinamycin and their DNVIP(LA)binding/alkylation properties. Trimethyl-4-phosphonocrotonate is also used as a reagent in the Wttig reaction with isopropylmethylenehexanal in the study of intramolecular routes to hydrindanes. Trimethyl-4-phosphonocrotonate is a starting material used in the polymerization of lipids in inverted hexagonal phase.
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