2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; rac-Teriflunomide; USP Leflunomide Related Compound B;
杂质:
Leflunomide USP Related Compound B
CAS号:
108605-62-5
分子式:
C₁₂H₉F₃N₂O₂
外观:
白色固体
熔点:
228-230°C (dec.)
分子量:
270.21
储存:
Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Sparingly)
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective thanÂinjectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.
危险品信息:
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
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