2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42;
CAS号:
134036-52-5
分子式:
C₁₇H₁₄N₂O₃
状态：
Dark Yellow Solid
熔点：
>213°C (dec.)
分子量:
294.3
储存：
-20°C Freezer
溶解性:
Acetone, Chloroform, DMSO, Ethanol, Methanol
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
危险品信息:
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
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