α,α'-Bis[(2-Methoxyphenoxy)methyl]-1,4-piperazinediethanol-d8 is the isotope labelled analog of α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol, a metabolite of Ranolazine (R122500). Ranolazine is an anti-ischemic agent which modulates myocardial metabolism. α,α'-Bis[(2-methoxyphenoxy)methyl]-1,4-piperazinediethanol is also known to exhibit anti-anginal activities.