3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide; AP 24534; Iclusig
CAS号:
943319-70-8
分子式:
C₂₉H₂₇F₃N₆O
外观:
白色至Pale Beige Solid
熔点:
>175°C (dec.)
分子量:
532.56
储存:
Amber Vial, 冰箱, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly)
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor
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