Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
RTI 70 is a cocaine derivative that prevent cocaine and MK-801 inhibition of nicotinic acetylcholine receptor (nAChR). Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
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