 您的位置：对照品 > 对照品 > 杂质对照品 > |
|
|
|
| 产品基本信息 |
|
| 产品编号：A603643 |
| 产品名称：(1S,4R)-4-Amino-2-cyclopentene-1-methanol (-)-Dibenzoyl-L-tartaric Acid |
| 产品CAS： |
| 规格含量：1g |
| 产品价格：面议 |
| 联系我们: |
 |
|
 |
|
|
| 产品详细介绍 |
| 标准品编号: |
A603643 |
| 名称: |
(1S,4R)-4-Amino-2-cyclopentene-1-methanol (-)-Dibenzoyl-L-tartaric Acid |
| 备用CAS: |
136522-35-5 |
| 分子式: |
C₆H₁₁NO • C₁₈H₁₄O₈ |
| 状态： |
白色固体 |
| 分子量: |
113.163583 |
| 溶解性: |
DMSO; Methanol |
| 类别: |
Building Blocks; Chiral Molecules; |
| 应用: |
(1S,4R)-4-Amino-2-cyclopentene-1-methanol (-)-Dibenzoyl-L-tartaric Acid is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| 参考: |
|
|
|
|
|
|
