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产品基本信息
产品编号：L465880
产品名称：Linaclotide
产品CAS：851199-59-2
规格含量：100mg
产品价格：面议
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产品详细介绍
标准品编号:
L465880
名称:
Linaclotide
别名:
L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); 11: PN: WO2008151257 SEQID: 55 claimed protein; 13: PN: WO2008151257 SEQID: 57 Claimed Protein; 2074: PN: US20090062207 SEQID: 3 Claimed Protein; 40: PN: WO2010065751 SEQID: 55 Claimed Protein; 42: PN: WO2010065751 SEQID: 57 claimed protein; 55: PN: US20100152118 SEQID: 55 Claimed Protein; 55: PN: WO2011069038 SEQID: 55 Claimed Sequence; 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein; 57: PN: WO2011069038 SEQID: 57 Claimed Sequence; 57: PN: WO2012037380 SEQID: 57 Claimed Protein;
CAS号:
851199-59-2
参考CAS号:
851199-60-5
分子式:
C₅₉H₇₉N₁₅O₂₁S₆
外观:
白色固体
熔点:
231-235°C (dec.)
分子量:
1526.74
储存:
Hygroscopic, 冰箱, under inert atmosphere
溶解度:
DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
参考文献
Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);
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