2-C-Methyl-4,5-O-(1-methylethylidene)-D-arabinonic AcidEthyl Ester Cyclic Sulfatecan beutilized for the synthesis of2'-deoxy-2'-fluoro-2'-C-methylcytidine (I) (PSI-6130), which is a potent and selective inhibitor of HCV NS5B polymerase. It also has potential applications for the synthesis of related antiviral agents.