产品编号：A604735
产品规格：10g
产品价格：面议
| 标准品编号: | A604735 |
| 名称: | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide |
| 别名: | N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide; Abacavir - In House Impurity; Abacavir Impurities |
| 杂质: | Abacavir - In House Impurity |
| CAS号: | 171887-03-9 |
| 分子式: | C₅H₄Cl₂N₄O |
| 状态： | 灰白色至浅褐色固体 |
| 熔点： | >251°C (dec.) |
| 分子量: | 207.02 |
| 储存： | Amber Vial, 冰箱保存, Under inert atmosphere |
| 溶解性: | DMSO, Methanol |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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