产品编号：A780100

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	A780100
名称:	AS-703026
别名:	N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;
CAS号:	1236699-92-5
分子式:	C₁₅H₁₅FIN₃O₃
分子量:	431.2
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Potent MEK inhibitor.
文献	Billadeau, D., et al.: Cancer Res., 55, 3640 (1995), Kolch, W., et al.: Biochem. J., 351, 289 (2000), Smith, M., et al.: Leukemia, 17, 274 (2003), Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),