产品编号：A790040

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	A790040
名称:	Ataciguat
别名:	5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; HMR 1766;
CAS号:	254877-67-3
分子式:	C₂₁H₁₉Cl₂N₃O₆S₃
分子量:	576.49
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
文献	Butt, E., et al.: J. Biol. Chem., 269, 14509 (1994), De Angelis, L., et al.: Diabetologia, 44, 1155 (2001), Schafer, A., et al.: Biochem. Pharmacol., 65, 397 (2003), Massberg, S., et al.: Blood, 103, 136 (2004), Stasch, J., et al.: J. Clin. Invest., 116, 2552 (2006),