产品编号：C014995
产品规格：5mg
产品价格：面议
| 标准品编号: | C014995 |
| 名称: | C646 |
| 别名: | 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid; C 646 |
| CAS号: | 328968-36-1 |
| 分子式: | C₂₄H₁₉N₃O₆ |
| 外观: | Dark Orange Solid |
| 熔点: | >215°C (dec.) |
| 分子量: | 445.42 |
| 储存: | Amber Vial, -20°C Freezer, Under inert atmosphere |
| 溶解度: | DMSO (Slightly), Methanol (Slightly, Heated) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients. |
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