产品编号：C175180

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	C175180
名称:	(S)-(-)-Canadine
别名:	(S)-5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine; Canadine; (-)-Canadine; (-)-Tetrahydroberberine; (-)-α-Canadine; (S)-(-)-7,8,13,13a-Tetrahydroberberine; (S)-(-)-Tetrahydroberberine; (S)-Canadine; (S)-Tetrahydroberberine; 9,10-Dimethoxy-2,3-(methylenedioxy)-13aα-berbine; l-Canadine; α-Canadine
CAS号:	5096-57-1
分子式:	C₂₀H₂₁NO₄
外观:	Pale Yellow to 淡黄色固体
熔点:	132-134°C
分子量:	339.39
储存:	冰箱保存
溶解度:	Chloroform, Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated)
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Phenethylamines/Amphetamines;
应用:	(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.
参考文献	Sun, H. et al.: Bioorg. Med. Chem., 21, 856 (2013); Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010); Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009); Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006); Yamahara, J. et al.: Chem. Pharm. Bull., 24, 1909 (1976)