产品编号：C377870

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	C377870
名称:	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
别名:	GDC-0068; Ipatasertib; RG 7440;
CAS号:	1001264-89-6
分子式:	C₂₄H₃₂ClN₅O₂
外观:	Peach Solid
熔点:	>106°C (dec.)
分子量:	458
储存:	Hygroscopic, 冰箱保存, under inert atmosphere
溶解度:	Acetonitriele (Slightly), DMSO (Slightly), Methanol (Slightly)
类别:	Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
参考文献	Jie, L., et al.: Clin. Cancer. Res., 10, 1078 (2013);