产品编号：C988365

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	C988365
名称:	11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
别名:	12-Hydroxy Nevirapine;
CAS号:	133627-24-4
分子式:	C₁₅H₁₄N₄O₂
外观:	Pale Yellow to Light Brown Solid
熔点:	>184ºC (dec.)
分子量:	282.3
储存:	冰箱保存
溶解度:	DMSO (Slightly), Methanol (Slightly)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Benzodiazepines;
应用:	11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, is a metabolite of Nevirapine (N391275), which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. It is also an antiviral.
参考文献	Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991), Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993), Guay, L.A., et al.: Lancet, 354, 795 (1999),

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