产品编号：D233025
产品规格：10mg
产品价格：面议
| 标准品编号: | D233025 |
| 名称: | (2'R)-2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-uridine |
| CAS号: | 1244762-86-4 |
| 分子式: | C₁₆H₂₇FN₂O₅Si |
| 外观: | 白色固体 |
| 熔点: | 230-232°C |
| 分子量: | 374.48 |
| 储存: | -20°C Freezer |
| 溶解性: | DMSO (Slightly), Methanol (Slightly) |
| 种类: | Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | (2'R)-2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
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