产品编号：D288865
产品规格：2mg
产品价格：面议
| 标准品编号: | D288865 |
| 名称: | Descyclopropyl Abacavir |
| 别名: | (1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentene-1-methanol; USP Abacavir Related Compound A; Abacavir EP Impurity C; Abacavir Related Compound A; Abacavir Impurities; Abacavir Intermediates |
| 杂质: | Abacavir EP Impurity C; Abacavir USP Related Compound A |
| CAS号: | 124752-25-6 |
| 分子式: | C₁₁H₁₄N₆O |
| 外观: | 白色至淡黄色固体 |
| 熔点: | 177-179ºC |
| 分子量: | 246.27 |
| 储存: | -20ËšC Freezer |
| 溶解性: | DMSO (Slightly), Methanol (Slightly, Heated) |
| 种类: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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