产品编号：D473360

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	D473360
名称:	N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide
CAS号:	338801-69-7
分子式:	C₄₅H₆₆N₄O₆Si
分子量:	787.11
溶解性:	Acetone, Acetonitrile
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-[(2R,4R,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-L-phenylalaninamide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the major causative agent in Alzheimer disease (AD).
参考文献	Dias, L.C., et al.: Synthesis., 4, 603 (2003); Nadin, A., et al.: Tetrahedron., 57, 1861 (2001);