产品编号：D476325

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	D476325
名称:	Dimethyloxaloylglycine
别名:	N-[(Methoxycarbonyl)methyl]oxamic Acid Methyl Ester; N-(methoxyoxoacetyl)glycine Methyl Ester; DMOG;
CAS号:	89464-63-1
分子式:	C₆H₉NO₅
外观:	白色至Pale Pink Solid
熔点:	46-48°C
分子量:	175.14
储存:	冰箱保存
溶解性:	DMSO, Ethanol, Methanol
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).
参考文献	Milkiewicz, M., et al.: J. Physiol., 560, 21 (2004), Koivunen, P., et al.: J. Biol. Chem., 279, 9899 (2004, Asikainen, T.M., et al.: Free Radic. Biol. Med., 38, 1002 (2005),Asikainen, T.M., et al.: Proc. Natl. Acad. Sci. USA, 102, 10212 (2005), Ockaili, R., et al.: Am. J. Physiol. Heart Circ. Physiol., 289, H522 (2005)