产品编号：D528803

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	D528803
名称:	度鲁特韦-d6；Dolutegravir-d6
别名:	(4R,12aS)-N-[(2,4-Difluorophenyl)methyl-d2]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-(methyl-d3)-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-4-d-9-carboxamide;
CAS号:	1407166-95-3
参考CAS:	未标记：1051375-16-6
分子式:	C₂₀H₁₃D₆F₂N₃O₅
分子量:	425.42
种类:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
应用:	Dolutegravir-d6 is an isotopic analog of Dolutegravir (D528800) which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
参考文献	Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);