产品编号：E608165

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	E608165
名称:	Everolimus, Cyclosporine and Tacrolimus Mix Standard
分子式:	C₅₃H₈₃NO₁₄ • C₆₂H₁₁₁N₁₁O₁₂ • C₄₄H₆₉N
分子量:	958.2212026
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Everolimus (E945400) is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Cyclosporine(C990065) is an immunopsupressent thought to bind to cyclophilin in T-lymphocytes. Tacrolimus (F370000) is also an immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
参考文献	Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Feine, O., et al.: Cell Cycle, 13, 1727-36 (2014); Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)