产品编号：E898795

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	E898795
名称:	6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride
CAS号:	502648-93-3
参考CAS:	769917-28-4
分子式:	C₁₂H₁₆N₄S • 2(HCl)
外观:	白色固体
分子量:	248.3523646
储存:	冰箱保存, under inert atmosphere
溶解度:	Methanol; Ethyl Acetate
种类:	Building Blocks; Miscellaneous;
应用:	6-Ethyl-4-(1-piperazinyl)thieno[2,3-d]pyrimidine Hydrochloride is an intermediate used in the synthesis of 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride (E926745), which is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
参考文献	Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);