产品编号：E918910

产品规格：500mg

产品价格：面议

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产品详情

标准品编号:	E918910
名称:	Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate
别名:	2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic Acid Ethyl Ester; Ethyl 2-(4-Hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
CAS号:	161797-99-5
分子式:	C₁₃H₁₃NO₃S
外观:	白色固体
熔点:	183-184ºC
分子量:	263.31
储存:	冰箱保存
溶解度:	DMSO (Slightly), Methanol (Very Slightly)
种类:	Building Blocks; Miscellaneous;
应用:	Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
参考文献	Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)