产品编号：E926745

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	E926745
名称:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride
别名:	4-(4-(1,3,4-Thiadiazol-2-yl)piperazin-1-yl)-6-ethylthieno[2,3-d]pyrimidine Hydrochloride; MI-nc (hydrochloride);
CAS号:	1359873-45-2
参考CAS:	1359873-35-0
分子式:	C₁₄H₁₇ClN₆S₂
外观:	白色至白色固体
熔点:	>188°C (dec.)
分子量:	368.91
储存:	冰箱保存
溶解度:	DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
参考文献	Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);