产品编号：G932035
产品规格：2.5mg
产品价格：面议
| 标准品编号: | G932035 |
| 名称: | G-1 |
| 别名: | (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone |
| CAS号: | 881639-98-1 |
| 分子式: | C₂₁H₁₈BrNO₃ |
| 外观: | 白色固体 |
| 熔点: | 170-173°C |
| 分子量: | 412.28 |
| 储存: | -20°C Freezer |
| 溶解度: | DMSO (Slightly), Methanol (Slightly, Heated) |
| 种类: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | G-1 is a potent and selective G protein-coupled estrogen receptor (GPER) agonist (Ki = 11 nM, EC50 = 2 nM); displays no activity at ERα and ERβ at concentrations up to 10 μM. Increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50 values are 0.7 and 1.6 nM respectively) in vitro. Blocks MCF-1 cell cycle progression at the G1 phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis. |
| 参考文献 | |
