产品编号：H491020

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	H491020
名称:	8-Hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
别名:	5,6,7,8-Tetrahydro-8-hydroxy-1-naphthalenecarboxylic Acid
CAS号:	74145-11-2
分子式:	C₁₁H₁₂O₃
外观:	白色至Off-white
分子量:	192.21
储存:	Room Temperature
溶解度:	DMF; DMSO;
种类:	Building Blocks; Miscellaneous;
应用:	8-Hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid is an intermediate in the synthesis of N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide (A795305), an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
参考文献	Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)