产品编号：H999750

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	H999750
名称:	HZ-52
别名:	2-[[4-([1,1'-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid; HZ 52;
CAS号:	1077626-51-7
分子式:	C₂₄H₂₆ClN₃O₂S
分子量:	456
种类:	Research Tools;
应用:	A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
参考文献	Greiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008);